Epitalon
A synthetic tetrapeptide modeled on the pineal gland's epithalamin that stimulates telomerase activity, extends telomere length, and recalibrates neuroendocrine and circadian function toward youthful baselines.
A synthetic tetrapeptide modeled on the pineal gland's epithalamin that stimulates telomerase activity, extends telomere length, and recalibrates neuroendocrine and circadian function toward youthful baselines.
Epitalon activates telomerase (hTERT) expression, leading to telomere elongation and reduced replicative senescence in somatic cells. It normalizes melatonin secretion via pineal gland stimulation and modulates cortisol rhythms through the hypothalamic-pituitary axis. Its antioxidant action reduces lipid peroxidation and increases superoxide dismutase activity, supporting longevity at the cellular level.
- [1]Khavinson VKh, et al. (2003). Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bulletin of Experimental Biology and Medicine, 135(6):590-592.
- [2]Anisimov VN, et al. (2003). Inhibitory effect of the peptide epitalon on the development of spontaneous mammary tumors in HER-2/neu transgenic mice. International Journal of Cancer, 101(1):7-10.
- [3]Kossoy G, et al. (2006). Effect of the synthetic pineal peptide epitalon on spontaneous carcinogenesis in female C3H/He mice. In Vivo, 20(2):253-257.
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