Semax
A heptapeptide analog of the ACTH(4-7) fragment that potently upregulates BDNF and NGF expression, supporting neural circuit protection, synaptic plasticity, and cognitive performance under stress.
A heptapeptide analog of the ACTH(4-7) fragment that potently upregulates BDNF and NGF expression, supporting neural circuit protection, synaptic plasticity, and cognitive performance under stress.
Semax upregulates brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in hippocampal and cortical regions, supporting synaptic plasticity and neuronal survival. It modulates dopaminergic and serotonergic tone, reduces neuroinflammatory cytokines, and enhances cerebral blood flow. Clinical and preclinical work shows improvements in attention, working memory, and stress resilience.
- [1]Kolomin T, et al. (2013). Peptide SEMAX affects the expression of genes related to the immune and vascular systems in mouse brain: a transcriptome analysis. Journal of Molecular Neuroscience, 52(3):328-340.
- [2]Makhanova MV, et al. (2012). Comparative analysis of Semax and its C-terminal peptide PGP effects on learning and memory in rats. Neuropeptides, 46(5):251-258.
- [3]Shadrina MI, et al. (2001). Heptapeptide Semax stimulates the expression of neurotrophins and their receptors in the brain of rats. Bulletin of Experimental Biology and Medicine, 131(5):464-466.
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