Glutathione
The body's most abundant endogenous antioxidant — a tripeptide (γ-glutamyl-cysteinyl-glycine) that neutralizes reactive oxygen species, recycles other antioxidants, and anchors Phase II cellular detoxification.
The body's most abundant endogenous antioxidant — a tripeptide (γ-glutamyl-cysteinyl-glycine) that neutralizes reactive oxygen species, recycles other antioxidants, and anchors Phase II cellular detoxification.
Glutathione directly scavenges hydroxyl radicals and lipid peroxides, acting as a substrate for glutathione peroxidase (GPx) and glutathione S-transferases (GSTs) in Phase II detoxification. It regenerates oxidized ascorbate and alpha-tocopherol, sustaining the broader antioxidant network. The GSH/GSSG redox ratio regulates NF-κB and AP-1 transcription factors, influencing inflammation thresholds and apoptosis decisions at the cellular level.
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- [3]Ballatori N, et al. (2009). Glutathione dysregulation and the etiology and progression of human diseases. Biological Chemistry, 390(3):191-214.
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